The effects of mutational processes and selection on driver mutations across cancer types
oleh: Daniel Temko, Ian P. M. Tomlinson, Simone Severini, Benjamin Schuster-Böckler, Trevor A. Graham
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-05-01 |
Deskripsi
A central question in cancer research is how specific driver mutations are acquired and maintained during cancer development. Here Temko et al. use public sequencing data to infer the effect of mutation and selection on a set of driver mutations and suggest that selection frequently dominates.