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Cryptococcal infection is a chronic opportunistic infection in patients with the Human Immunodeficiency Virus (HIV). A rare case of cryptococcal lymphadenitis is presented here in a 27-year-old woman with an enlarged cervical lymph node. Fine needle aspiration from the involved lymph nodes showed variable-sized, rounded yeast cells surrounded by halos with a prominent capsule. Early diagnosis by fine-needle aspiration is essential and reduces morbidity and mortality.