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Ayun Cassell,1 Mohamed Jalloh,1 Medina Ndoye,1 Bashir Yunusa,2 Mouhamadou Mbodji,1 Abdourahmane Diallo,1 Omar Gaye,1 Issa Labou,1 Lamine Niang,1 Serigne Gueye1 1Department of Urology and Andrology, Hopital General de Grand Yoff, Dakar, Senegal; 2Department of Surgery, Liberia College of Physicians and Surgeons, Monrovia, LiberiaCorrespondence: Ayun CassellDepartment of Urology and Andrology, Hopital General de Grand Yoff, Dakar, SenegalTel +221770135805Email ayuncasselliii@gmail.comAbstract: Testicular cancer is a common malignancy in young males with higher incidence in developed nations but with the lowest incidence in Africa (0.3– 0.6/100 000). Ironically, the global testicular cancer mortality rate has shown a reverse trend to its incidence with higher rates in low- and middle-income countries (0.5 per 100 000) than in high-income countries. Data from GLOBOCAN 2008 have shown relatively high mortality rates in sub-Saharan countries like Mali, Ethiopia, Niger and Malawi. The prognosis of testicular tumor is good with remarkable chemosensitivity to cisplatin-based regimen. Early diagnosis, careful staging and a multidisciplinary management approach is crucial to achieve this optimal result. These results are achievable in the sub-Saharan region if the relevant resources are appropriated for cancer care and clinical guidelines are formulated in a regional context.Keywords: germ cell, orchidectomy, testicular cancer