NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells
oleh: Hani Alrefai, Khalid Muhammad, Ronald Rudolf, Duong Anh Thuy Pham, Stefan Klein-Hessling, Amiya K. Patra, Andris Avots, Valesca Bukur, Ugur Sahin, Stefan Tenzer, Matthias Goebeler, Andreas Kerstan, Edgar Serfling
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-05-01 |
Deskripsi
Regulatory B cells are important for preventing skin autoimmunity. Here the authors show that NFATc1 suppresses IL-10 transcription in regulatory B cells, and inhibiting NFATc1 decreases immunopathology in a mouse model of imiquimod-induced skin inflammation.