The effect of the cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway on organ inflammatory injury and fibrosis
oleh: Yuliang Liu, Yuliang Liu, Yuliang Liu, Yihui Li, Yihui Li, Yihui Li, Li Xue, Li Xue, Li Xue, Jie Xiao, Jie Xiao, Jie Xiao, Pengyong Li, Pengyong Li, Pengyong Li, Wanlin Xue, Wanlin Xue, Wanlin Xue, Chen Li, Chen Li, Chen Li, Haipeng Guo, Haipeng Guo, Haipeng Guo, Yuguo Chen, Yuguo Chen, Yuguo Chen
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2022-12-01 |
Deskripsi
The cyclic GMP-AMP synthase-stimulator of interferon genes signal transduction pathway is critical in innate immunity, infection, and inflammation. In response to pathogenic microbial infections and other conditions, cyclic GMP-AMP synthase (cGAS) recognizes abnormal DNA and initiates a downstream type I interferon response. This paper reviews the pathogenic mechanisms of stimulator of interferon genes (STING) in different organs, including changes in fibrosis-related biomarkers, intending to systematically investigate the effect of the cyclic GMP-AMP synthase-stimulator of interferon genes signal transduction in inflammation and fibrosis processes. The effects of stimulator of interferon genes in related auto-inflammatory and neurodegenerative diseases are described in this article, in addition to the application of stimulator of interferon genes-related drugs in treating fibrosis.