Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors
oleh: Jing-Kang Shen, Mao-Sheng Cheng, Yu-Fang Shi, Zhi-Heng Yang, Chao Yu, Pei-Wei Fan, Wen-Yan Li, Xu-Qiong Xiong, Dong-Mei Zhao
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2012-05-01 |
Deskripsi
A series of novel quinoline-3-carboxamide derivatives <strong>10</strong>–<strong>17</strong> and <strong>23</strong>–<strong>27</strong> were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds <strong>24</strong> and <strong>26</strong> displayed the best activity against CETP with the same inhibitory rate of 80.1%.