Antibody isotype responses in Balb/c mice immunized with the cytoplasmic repetitive antigen and flagellar repetitive antigen of Trypanosoma cruzi
oleh: Valéria RA Pereira, Virginia Maria B Lorena, Alinne Fernanda A Verçosa, Edmilson D Silva, Antonio GP Ferreira, Ulisses R Montarroyos, Ana P Galvão Silva, Yara M Gomes
| Format: | Article |
|---|---|
| Diterbitkan: | Fundação Oswaldo Cruz (FIOCRUZ) 2003-09-01 |
Deskripsi
In the present report we analyzed the levels of IgG1, IgG2a, IgG2b and IgG3 isotypes from Balb/c mice immunized with cytoplasmic repetitive antigen (CRA), and flagelar repetitive antigen (FRA) of Trypanosoma cruzi. The immunization was done by subcutaneous route three times (20 days apart) and the analysis was performed 14 days after each treatment. CRA-immunized mice produced high levels of all IgG isotypes, mainly IgG3 and IgG1. FRA-immunization elicited only high levels of IgG1.