Zika virus RNA structure controls its unique neurotropism by bipartite binding to Musashi-1
oleh: Xiang Chen, Yan Wang, Zhonghe Xu, Meng-Li Cheng, Qing-Qing Ma, Rui-Ting Li, Zheng-Jian Wang, Hui Zhao, Xiaobing Zuo, Xiao-Feng Li, Xianyang Fang, Cheng-Feng Qin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-02-01 |
Deskripsi
Human RNA binding protein Musashi-1 binds various host transcripts as well as Zika virus RNA in neural progenitor cells. Here, Chen et al. characterise the interactions between Musashi-1 and its binding site using a combination of molecular and biophysical methods to shed light on its role in viral neurotropism.