Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice
oleh: Aniruddha Adhikari, Susmita Mondal, Tanima Chatterjee, Monojit Das, Pritam Biswas, Ria Ghosh, Soumendra Darbar, Hussain Alessa, Jalal T. Althakafy, Ali Sayqal, Saleh A. Ahmed, Anjan Kumar Das, Maitree Bhattacharyya, Samir Kumar Pal
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-08-01 |
Deskripsi
Adhikari et al. use the redox modulatory abilities of citrate functionalized Mn3O4 nanoparticles to ameliorate oxidative damage in murine disease model of chronic kidney disease (CKD). This nanomedicine works by protecting structural and functional integrity of mitochondria from oxidative injury, reducing intracellular ROS, downregulating pro-inflammatory cytokines and maintaining cellular redox homeostasis.