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The advancement of nanobiotechnology is happening with leap and bound and the maneuvering in application of nanofluids in medical field is emerged as major research topic in recent times. Motivated by key applications in this direction, the current investigation embarks to explore the hybrid nanofluid dynamics in a ciliated inclined microchannel with various physical impacts, electromagnetohydrodynamic (EMHD), gyrotactic microorganisms, activation energy, and solar radiation. The pertinent equations of motion are tackled with low Reynolds number, long wavelength, and Debye–Huckel linearization approximations. The resulting equations of motion after simplifications tackled with the implementation numerical computations in Mathematica. The variations of pivotal physical parameters on the flow dynamics and thermal axiom are exhibited with graphical illustrations. It is worth mention here that the Hartmann, Grashof, electroosmotic, buoyancy, bioconvection parameters surged the hybrid nanofluid velocity adjacent to right wall. The temperature goes down with the thermal radiation and thermophoresis parameters. The radiation, Brownian motion, thermophoresis parameters reinforce the nanoparticle volume fraction, and motile microorganisms. The reported investigation has great significance for physiological fluid transport in the gastrointestinal tract, managing the bleeding by manipulating the magnetic field and in drug infusion mechanism.