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Hypotensive transfusion reaction is a distinct category of adverse sequelae of transfusion characterized by an early and abrupt onset of hypotension, typically resolving promptly upon discontinuation of the transfusion. The primary mechanism behind this reaction seems to be the accumulation of bradykinin in the transfused blood product during processing. The authors wish to highlight a case of isolated hypotensive reaction following administration of leukoreduced platelets in an Indian male patient, which required vasopressors. Awareness of the risk factors and clinical presentation for this type of reaction are vital for proper patient care and the prevention of future incidents.