F-actin mechanics control spindle centring in the mouse zygote
oleh: Agathe Chaigne, Clément Campillo, Raphaël Voituriez, Nir S. Gov, Cécile Sykes, Marie-Hélène Verlhac, Marie-Emilie Terret
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-01-01 |
Deskripsi
How the mitotic spindle is positioned in the centre of the cell during the first mitotic division is not clear. Here Chaigne et al.show that the pronucleus coarsely centres using F-actin/Myosin-Vb dynamics, and the metaphase plate is finely centred by an F-actin cage influenced by high cortical tension.