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Pelger-Huet anomaly (PHA) is a rare benign genetic disorder affecting terminal differentiation of granulocytes. Granulocytes have hyposegmented nuclei with normal cytoplasmic granularity and perform immune function. Knowledge about PHA is necessary to avoid misdiagnosis of hyposegmented granulocytes as increased band forms (bandemia) and to differentiate it from pseudo Pelger-Huet cells found in certain pathological conditions. Here, we report a case of PHA in neutrophils of a 46-year-old female found during routine peripheral smear examination. Further work up in family members revealed her siblings and her son were also having Pelger-Huet neutrophils in peripheral smear.