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<p>Abstract</p> <p>Background</p> <p>Carbapenem resistant <it>Enterobacteriaceae</it> is a worldwide threat, with increasing prevalence in many countries. Restricted usage of higher end antibiotics, especially carbapenem is of great importance in tackling these super bugs. Purpose of this retrospective study was to analyse the impact of antibiotic stewardship activities on the prevalence of carbapenem resistant <it>Enterobacteriaceae</it> in our hospital.</p> <p>Findings</p> <p>In the first Quarter of 2009, average usage of carbapenem group of antibiotics was 955 vials a month while in 2010, the usage dropped to 745 vials per month. Carbapenem resistant <it>E.coli</it> rate dropped from 3.7% in 2009 to 1.6% in 2010 and Klebsiella rate reduced from 6% in 2009 to 3.6% in 2010.</p> <p>Conclusions</p> <p>Strict antibiotic stewardship strategies in conjunction with good infection control practices are useful in restricting higher end antibiotic usage and reducing the prevalence of carbapenem resistant <it>Enterobacteriaceae.</it></p>