Ring-expansion synthesis and crystal structure of dimethyl 4-ethyl-1,4,5,6,7,8-hexahydroazonino[5,6-b]indole-2,3-dicarboxylate
oleh: Van Tuyen Nguyen, Elena A. Sorokina, Anna V. Listratova, Leonid G. Voskressensky, Nikolai N. Lobanov, Pavel V. Dorovatovskii, Yan V. Zubavichus, Victor N. Khrustalev
| Format: | Article |
|---|---|
| Diterbitkan: | International Union of Crystallography 2017-03-01 |
Deskripsi
The title compound, C20H24N2O4, is the product of a ring-expansion reaction from a seven-membered hexahydroazepine to a nine-membered azonine. The azonine ring of the molecule adopts a chair–boat conformation. In the crystal, molecules are linked by bifurcated N—H...(O,O) hydrogen bonds, generating [010] zigzag chains. The title compound shows inhibitory activity against acetylcholinesterase and butyrylcholinesterase, and might be considered as a candidate for the design of new types of anti-Alzheimer's drugs.