Research progress on the role of HMGB1 signal pathway in bronchial asthma
oleh: SUN Ying, YANG Zhian, HE Yao, YU Qin
| Format: | Article |
|---|---|
| Diterbitkan: | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2023-04-01 |
Deskripsi
High mobility group box 1 protein (HMGB1), as a ubiquitous nuclear protein, expresses in almost all cells. After activation and release, HMGB1 binds to its receptor and mediates pulmonary inflammatory response. HMGB1 signaling pathway is closely related to the occurrence and development of bronchial asthma. Related targeted drug therapy has been carried out in animal test and in clinical trials.