Insufficient Iron Improves Pristane-Induced Lupus by Promoting Treg Cell Expansion

oleh: Xiaofei Gao, Xiaofei Gao, Xiaofei Gao, Xiaofei Gao, Yang Song, Yang Song, Yang Song, Yang Song, Shuang Lu, Shuang Lu, Shuang Lu, Shuang Lu, Longyuan Hu, Longyuan Hu, Longyuan Hu, Longyuan Hu, Meiling Zheng, Meiling Zheng, Meiling Zheng, Meiling Zheng, Sujie Jia, Sujie Jia, Ming Zhao, Ming Zhao, Ming Zhao, Ming Zhao

Format: Article
Diterbitkan: Frontiers Media S.A. 2022-02-01

Deskripsi

Trace element iron affects T cell biology, but the knowledge about the role of iron in regulating Treg cell expansion is limited. Treg cells play an important role in keeping peripheral T cell tolerance, increasing Treg cell expansion is a promising therapeutic method for SLE. Here we showed that iron deficiency promotes Treg cell expansion by reducing ROS accumulation, improving the disease progression of pristane-induced lupus. Increased oxidative stress inhibits Treg cell differentiation by inducing cell apoptosis. Our data suggest that altering iron metabolism promotes Treg cell expansion by preventing oxidation-induced cell death, which may provide a potential therapeutic strategy for SLE.