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Objective: To  determine the frequency and pattern of lipid abnormalities in diagnosed female patients        of coronary artery disease in a tertiary care hospital of Karachi. Methods: This cross-sectional study was conducted from January 2016 to August 2016. A total of 300 female patients of Coronary Artery Disease (CAD), diagnosed on the basis  of  angiography  were  in- cluded in the study. For detection of lipid profile abnormalities five ml of fasting venous sample of 10- 12 hours was obtained from the left median cubital vein under aseptic conditions. The blood was  centrifuged for 5 minutes. Automated  chemistry  analyzer  was  used  for  lipid  profile  measurement  via kits of the CYPRESS Laboratory (Langdorp, Belgium). Statistical analysis was done via SPSS version       17 and results were expressed as percentage and mean ± standard deviation. Results: Mean age of recruited females was 51.36 ±  13.71  years.  About  81.39%  of  patients  were  found with abnormal lipid profile. The frequency of low high-density lipoprotein cholesterol in studied population was 61.66%, high  triglycerides  19.33%  whereas;  high  low-density  lipoprotein  cholesterol  was 17.33% respectively. Combined two parameter dyslipidaemia patterns was  found  in  41.32%  fol- lowed by  mixed  dyslipidaemia  in  19.33%,  while  isolated  high-density  lipoprotein  hypocholesteraemia  in 12.00% of study population. Conclusion: We conclude that low levels  of  high-density  lipoprotein  cholesterol  and hypertriglyceridemia, in both combined and isolated pattern,  are  more  prevalent  in  Pakistani  females with CAD.The data from the current study may increase the knowledge of the guidelines for lipid low-     ering need in females.