Structural basis underlying the synergism of NADase and SLO during group A Streptococcus infection
oleh: Wei-Jiun Tsai, Yi-Hsin Lai, Yong-An Shi, Michal Hammel, Anthony P. Duff, Andrew E. Whitten, Karyn L. Wilde, Chun-Ming Wu, Robert Knott, U-Ser Jeng, Chia-Yu Kang, Chih-Yu Hsu, Jian-Li Wu, Pei-Jane Tsai, Chuan Chiang-Ni, Jiunn-Jong Wu, Yee-Shin Lin, Ching-Chuan Liu, Toshiya Senda, Shuying Wang
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
Structural and mutational analyses reveal interactions between NAD+-glycohydrolase and Streptolysin O critical for Group A Streptococcus virulence, validated in a murine infection model.