The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3
oleh: Simona Notova, François Bonnardel , Francesca Rosato, Lina Siukstaite, Jessica Schwaiger, Jia Hui Lim, Nicolai Bovin, Annabelle Varrot, Yu Ogawa, Winfried Römer, Frédérique Lisacek, Anne Imberty
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-09-01 |
Deskripsi
A curated lectin database, structural characterization, and in vitro assays show that choanoflagellate lectin SaroL-1 binds to cancer-related α-galactosylated epitopes and can be toxic to cancer cells through a carbohydrate-dependent pore-formation mechanism.