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Background and purpose: Cesarean hemorrhage is a common but preventable cause of maternal death and placenta invasion is a major cause of cesarean hemorrhage. This study aimed to compare inhalation anesthesia with isoflurane and Propofol anesthesia in cesarean bleeding in these patients. Materials and methods: This study was conducted as a randomized clinical trial with 15 placental adhesion patients who were candidates for cesarean section. Five patients were excluded by applying the exclusion criteria, and out of the other 10 patients, 5 underwent cesarean section with isoflurane and 5 with Propofol. Results: The comparison indicated that the volume of suctioned blood, the number of gasses used, the volume of serum received, packed-cell received and urinary output were significantly lower in the Propofol group (P≤0.05). Systolic and diastolic blood pressures were significantly close to basic figures in the Propofol group (P≤0.05), Heart rate, respiratory rate, temperature, and O2 saturation were not significantly different between the two groups (P≥0.05). Conclusion: The findings of this study recommended propofol anesthesia for the cesarian section in placenta adhesion. However, further studies with more cases are needed. (Clinical Trials Registry Number: IRCT20110213005825N3)