Structure, gating, and pharmacology of human CaV3.3 channel
oleh: Lingli He, Zhuoya Yu, Ze Geng, Zhuo Huang, Changjiang Zhang, Yanli Dong, Yiwei Gao, Yuhang Wang, Qihao Chen, Le Sun, Xinyue Ma, Bo Huang, Xiaoqun Wang, Yan Zhao
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
T-type calcium channels are implicated in many diseases. Here, multiple structures of CaV3.3 channel elucidate molecular mechanisms of T-type CaV channels activation at low voltage and interaction with different clinically used channel blockers.