Direct Conversion of 3-(2-Nitroethyl)-1<i>H</i>-Indoles into 2-(1<i>H</i>-Indol-2-yl)Acetonitriles
oleh: Alexander V. Aksenov, Nicolai A. Aksenov, Elena V. Aleksandrova, Dmitrii A. Aksenov, Igor Yu. Grishin, Elena A. Sorokina, Allison Wenger, Michael Rubin
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2021-10-01 |
Deskripsi
The recently discovered [4+1]-spirocyclization of nitroalkenes to indoles provided a convenient new approach to 2-(1<i>H</i>-indol-2-yl)acetonitriles. However, this reaction was complicated by the formation of inert 3-(2-nitroethyl)-1<i>H</i>-indole byproducts. Herein, we offer a workaround this problem that allows for effective transformation of the unwanted byproducts into acetonitrile target molecules.