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The essay stems from an idea of plots and knots as a language allowing a secular hermeneutics of interactions among phenomena and events, to show how material cultures and anthropological/symbolical practices connect with a new theoretical space. The second idea is that a critique to the limits of modernity, with its belief in an unlimited technological progress, and postmodernity, stating the impossibility of establishing a difference between biological/cultural world and between natural/artificial, has to undertake a redefinition of the relationships among nature/living organisms/rational beings. Finally, the essay proposes a critique of the category of development, in particular related to the new digital technologies. It is essential to tackle how their spreading in each space and time has emptied the latter of their natural and anthropological differences, reducing them to a virtual unicum which has replaced the real and the forms of narration that cultures elaborated of it.