klf2a couples mechanotransduction and zebrafish valve morphogenesis through fibronectin synthesis
oleh: Emily Steed, Nathalie Faggianelli, Stéphane Roth, Caroline Ramspacher, Jean-Paul Concordet, Julien Vermot
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-05-01 |
Deskripsi
In the developing heart, blood flow transmits mechanical signals to progenitor cells that ultimately leads to valve formation. Here, the authors identify the origin of the valve progenitor cells and fibronectin1bas a transcriptional target of the mechanotransduced signals responsible for valve formation.