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The purpose of this study was to investigate the effects of a facial mask in enhancing skin absorption of iriflophenone 3,5-C-β-D-diglucoside (1), iriflophenone 3-C-β-D-glucoside (2) and mangiferin (3). Partition coefficients (log Po/w) of 1–3 were determined. Facial essence containing Aquilaria crassna leaf extract was formulated and incorporated into a fabric facial mask. An in-vitro skin permeation of 1–3 from the formulation with and without the mask through human skin was evaluated using Franz diffusion cells. Log Po/w of 1–3 were -1.03 ± 0.14, -0.54 ± 0.01 and 0.26 ± 0.01, respectively. The permeations of 1–3 from the formulation without fabric mask were only 0.26%, 0.58% and 0.61% of applied dose, respectively while those with the fabric mask were 0.79%, 1.08% and 0.70% of applied dose, respectively. In conclusion, the fabric mask enhances the skin permeation of the hydrophilic compounds 1, 2 more than that of compound 3, which is less hydrophilic.