A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas
oleh: Keith Smith, Gamal A. El-Hiti, Amany S. Hegazy, Benson Kariuki
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2011-09-01 |
Deskripsi
Lithiation of N'-benzyl-N,N-dimethylurea and its substituted derivatives with t-BuLi (3.3 equiv) in anhydrous THF at 0 °C followed by reaction with various electrophiles afforded a range of 3-substituted isoindolin-1-ones in high yields.