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Sugar Efflux transporters (SWEET) are involved in diverse biological processes of plants. Pathogens have exploited them for nutritional gain and subsequently promote disease progression. Recent studies have implied the involvement of potato <i>SWEET</i> genes in the most devastating late blight disease caused by <i>Phytophthora infestans</i>. Here, we identified and designated 37 putative <i>SWEET</i> genes as <i>StSWEET</i> in potato. We performed detailed in silico analysis, including gene structure, conserved domains, and phylogenetic relationship. Publicly available RNA-seq data was harnessed to retrieve the expression profiles of <i>SWEET</i> genes. The late blight-responsive SWEET genes were identified from the RNA-seq data and then validated using quantitative real-time PCR. The <i>SWEET</i> gene expression was studied along with the biotrophic (<i>SNE1</i>) and necrotrophic (<i>PiNPP1</i>) marker genes of <i>P. infestans</i>. Furthermore, we explored the co-localization of <i>P. infestans</i> resistance loci and <i>SWEET</i> genes. The results indicated that nine transporter genes were responsive to the <i>P</i>. <i>infestans</i> in potato. Among these, six transporters, namely <i>StSWEET10</i>, 12, 18, 27, 29, and 31, showed increased expression after <i>P. infestans</i> inoculation. Interestingly, the observed expression levels aligned with the life cycle of <i>P. infestans</i>, wherein expression of these genes remained upregulated during the biotrophic phase and decreased later on. In contrast, <i>StSWEET13</i>, 14, and 32 didn’t show upregulation in inoculated samples suggesting non-targeting by pathogens. This study underscores these transporters as prime <i>P. infestans</i> targets in potato late blight, pivotal in disease progression, and potential candidates for engineering blight-resistant potato genotypes.