The neuroprotective mechanism of lithium after ischaemic stroke
oleh: Beina Chen, Manman Zhang, Ming Ji, Dianjun Zhang, Binjie Chen, Wenliang Gong, Xinyu Li, Yuefei Zhou, Chengyi Dong, Gehua Wen, Xiaoni Zhan, Xiafang Wu, Huiya Yuan, Enyu Xu, Maosheng Xia, Alexei Verkhratsky, Baoman Li
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-02-01 |
Deskripsi
Using the MCAO stroke mouse model, Chen et al. identify pathways that underlie the neuroprotective properties of lithium by using inhibitors of AKT/GSK3β/β-catenin and AKT/FoxO3a/β-catenin signaling. They report that the inhibitors reverse the protective effects of lithium thus conclude that both pathways are key for lithium-mediated neuroprotection.