Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals
oleh: Tobias John, Elisabete Pires, Svenja S. Hester, Eidarus Salah, Richard J. Hopkinson, Christopher J. Schofield
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
Formaldehyde is a potent toxic electrophile at high concentrations; however its potential regulatory roles remain unknown. Here, the authors report that formaldehyde can react with terminal proline-containing proteins to generate stable 5,5-bicyclic aminal termini that modulate protein function.