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This paper presents the study of heat and mass transfer in two-dimensional magnetohydrodynamic nanofluid flow over a cone/plate. By linearization and finite difference discretization, we numerically solved ordinary differential equations obtained from the partial differential equations (PDEs) by using similarity transformation. The impact of non-dimensional parameters, such as Prandtl number, Dufour number, Schmidt number, and Soret number, on velocity, temperature, and concentration has been examined from the graphs and tables. It has been noted that, compared to the rotating plate, heat and mass transfer properties of the flow over the rotating cone are more promising.