Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing
oleh: Zhi-xue Cheng, Chang Guo, Zhuang-gui Chen, Tian-ci Yang, Jian-ying Zhang, Jie Wang, Jia-xin Zhu, Dan Li, Tian-tuo Zhang, Hui Li, Bo Peng, Xuan-xian Peng
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-07-01 |
Deskripsi
Serum-resistant bacteria can escape complement killing in the bloodstream. Here, using metabolomics and metabolite perturbations, the authors describe an altered metabolic state in serum-resistant Escherichia coli and show that exogenous glycine potentiates elimination of pathogenic bacteria in vivo.