Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis
oleh: Judit Espana-Agusti, Anne Warren, Su Kit Chew, David J. Adams, Athena Matakidou
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-12-01 |
Deskripsi
Mutations in VHL have been linked to clear cell renal cancer, but the molecular mechanisms involved remain unclear. Here the authors generate a mouse model closely mimicking the human disease and show that VHL loss induces DNA replication stress that is rescued by the concomitant loss of PBRM1 permitting transformation.