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25 models are designed according to the orthogonal table, to study the comprehensive relationship between heat transfer and sealing characteristics in straight-through labyrinth seals with different geometrical parameters. The experimental investigations are carried out at different pressure ratios of 1.2, 1.3, 1.4, 1.6, 1.8. The results show that different geometry parameters brought obvious different influence on both leakage efficiency and heat transfer characteristics, and in which the parameters (H, c,β) have the most significant influence on leakage efficiency, and heat transfer characteristics under different pressure ratios, whose small changes in size can lead to performance optimization in leakage and heat transfer. The geometrical parameters always show consistent influence on leakage efficiency and heat transfer characteristics, while heat transfer characteristics show larger vibration with the increase of pressure ratio.