RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer
oleh: Nyam-Osor Chimge, Gillian H. Little, Sanjeev K. Baniwal, Helty Adisetiyo, Ying Xie, Tian Zhang, Andie O’Laughlin, Zhi Y. Liu, Peaches Ulrich, Anthony Martin, Paulette Mhawech-Fauceglia, Matthew J. Ellis, Debu Tripathy, Susan Groshen, Chengyu Liang, Zhe Li, Dustin E. Schones, Baruch Frenkel
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-02-01 |
Deskripsi
The tumour suppressor RUNX1 is often lost or mutated in oestrogen receptor-positive breast cancers. In this study, the authors demonstrate that the loss of RUNX1 unleashes oestrogen-mediated inhibition of AXIN1, a negative regulator of β-catenin, resulting in β-catenin signalling-mediated cancer cell proliferation and mitosis deregulation.