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Foam flooding (or injection of foam) is a common technology to enhance oil recovery. Although the effects of permeability on foam flooding were well studied in many laboratory experiments, little research has been focused on the specificity of low permeability. In this paper, a series of constant-quality nitrogen foam flow experiments were conducted to investigate the effects of permeability on the foam performance and oil displacement efficiency. Moreover, the results indicated that foam can be generated in low permeability porous media. With uniform experimental conditions, the higher permeability core has a bigger recovery amplification and greater decreasing range of water cut decline. Furthermore, the effect of microscopic heterogeneities of low permeability reservoir on foam displacement is considered. Moreover, experimental comparative analysis with different microscopic heterogeneity cores showed that, in low permeability condition, homogeneous porous media has a better prospects of oil-displacement. Finally, in this work, the results of the permeability effects on the foam performance and oil displacement efficiency exemplify a potential to apply the technology to low permeability reservoir.