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Yan Chen,1 Yao Lu,1 Robert J Lee,2 Guangya Xiang1 1School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, OH, USACorrespondence: Guangya XiangSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, Hubei 430030, People’s Republic of ChinaTel +86 27 83692793Email gyxiang1968@hotmail.comAbstract: Curcumin, a yellow-colored polyphenol extracted from the rhizome of turmeric root, is commonly used as a spice and nutritional supplement. It exhibits many pharmacological activities such as anti-inflammatory, anti-bacterial, anti-cancer, anti-Alzheimer, and anti-fungal. However, the therapeutic application of curcumin is limited by its extremely low solubility in aqueous buffer, instability in body fluids, and rapid metabolism. Nano delivery system has shown excellent potential to improve the solubility, biocompatibility and therapeutic effect of curcumin. In this review, we focus on the recent development of nano encapsulated curcumin and its potential for biomedical applications.Keywords: curcumin, nanoformulations, bioavailability, nanoparticles, therapy