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Primary Ciliary Dyskinesia (PCD) is a rare ciliopathic autosomal recessive genetic disorder that causes defect in the action of cilia lining the respiratory tract. In a total of 50% cases of situs inversus totalis fertility is preserved. Here, we report a case of situs inversus totalis with chronic respiratory ailment in a fertile male. A 60-year-old non smoker male, father of four children presented with recurrent episode of infection for past five years. Investigation was done which showed situs inversus totalis (Dextrocardia) with right lower lobe bronchiectasis. He was managed with antibiotics, mucolytics, bronchodilators and chest physiotherapy. Patient status improved well with above mentioned treatment.