Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor
oleh: Shaohua Li, Trung Duc Nguyen, Thuy Linh Nguyen, Tuan Anh Nguyen
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-04-01 |
Deskripsi
MicroRNA genes are transcribed to long primary transcripts called primary microRNAs, which are cleaved by Microprocessor. Here the authors employ high-throughput sequencing and Microprocessor assay to show that mismatches and wobble base pairs in primary microRNAs affect the accuracy and efficiency of Microprocessor processing.