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Objective: This study is an attempt to examine the transdifferentiation of bone marrowstromal cells (BMSCs) into tyrosine hydroxylase immunoreactive cells in parkinsonian ratsassociated with angiogenesis.Materials and Methods: In this study, Sprague-Dawley rats received unilateral stereotaxicinjections of 6-hydroxydopamine(6-OHDA) into the left corpus striatum and then weredivided into two groups. One group, the negative control, received only medium while theother group was treated with BMSCs. BMSCs were harvested from femur bones, labeledwith bromodeoxyuridine (BrdU) and then transplanted into parkinsonian rats, where a behavioralstudy and immunohistochemistry were used to evaluate the treatment.Results: The results showed statistically significant improvement in rotational behavior.Anti-BrdU antibody showed engraftment of the transplanted cells at the transplantationsite. Additionally, double immunolabeling confirmed that these cells were positive for neurofilament-200 and tyrosine hydroxylase (TH).Conclusion: It may be concluded that BMSCs transplants could engraft and differentiateinto TH immunoreactive cells which may cause recovery from motor deficits. Also, BMSCsmay contribute to angiogenesis at the transplantation site.