Fusion peptide is superior to co-expressing subunits for arming oncolytic herpes virus with interleukin 12

oleh: Hiroshi Fukuhara, Yuzuri Tsurumaki Sato, Jiangang Hou, Miwako Iwai, Tomoki Todo

Format: Article
Diterbitkan: Nature Portfolio 2023-03-01

Deskripsi

Fukuhara et al. evaluate different methods to express IL-12 as an immunostimulatory payload of oncolytic HSV-1 using G47∆ as the backbone. They find that expressing the two IL-12 subunits as a fusion peptide leads to superior efficacy of the oncolytic virus in tumor models, compared with a virus in which the subunits have been co-expressed.