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Documentary research whose objective was to analyze the trajectory of the Uniform Requirements for manuscripts submitted to biomedical periodicals. The 13 editions of the Uniform Requirements, covering between 1978, when the first edition was produced, and 2010, the last year of publishing at the time, were analyzed. These requirements were instituted by a group of editors in Vancouver, Canada, and aim to recommend standardizations for the presentation of manuscripts to scientific periodicals in the health area. Various changes were identified which had occurred in the versions, with the inclusion, revision and broadening of elements and themes which were described in the form of a summary, with emphasis on the current recommendations. The Requirements help authors and editors in the work of preparation, submission and dissemination of the production of scientific knowledge in the area of health, and this reflects the importance of knowledge of this document’s content – as well as of keeping up with its updates.