Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT.
oleh: Luis A Diaz, Catherine A Foss, Katherine Thornton, Sridhar Nimmagadda, Christopher J Endres, Ovsev Uzuner, Thorsten M Seyler, Slif D Ulrich, Janet Conway, Chetan Bettegowda, Nishant Agrawal, Ian Cheong, Xiaosong Zhang, Paul W Ladenson, Barry N Vogelstein, Michael A Mont, Shibin Zhou, Kenneth W Kinzler, Bert Vogelstein, Martin G Pomper
| Format: | Article |
|---|---|
| Diterbitkan: | Public Library of Science (PLoS) 2007-10-01 |
Deskripsi
Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinase (TK) whose substrate specificity is distinct from that of the major human TK. The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria.Eight subjects with suspected musculoskeletal infections and one healthy control were studied by a combination of [(124)I]FIAU-positron emission tomography and CT ([(124)I]FIAU-PET/CT). All patients with proven musculoskeletal infections demonstrated positive [(124)I]FIAU-PET/CT signals in the sites of concern at two hours after radiopharmaceutical administration. No adverse reactions with FIAU were observed.[(124)I]FIAU-PET/CT is a promising new method for imaging bacterial infections.