Bi-directional ribosome scanning controls the stringency of start codon selection
oleh: Yifei Gu, Yuanhui Mao, Longfei Jia, Leiming Dong, Shu-Bing Qian
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-11-01 |
Deskripsi
Start codon selection is commonly thought to occur through the unidirectional scanning of the mRNA by the 40 S ribosome. Here the authors provide evidence that the pre-initiation complex can backslide on the mRNA to initiate translation at upstream AUG codons.