Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy
oleh: Eric Lazear, Reza Ghasemi, Sarah M. Hein, John Westwick, Dan Watkins, Daved H. Fremont, Alexander Sasha Krupnick
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2017-02-01 |
Deskripsi
The use of high-dose interleukin-2 (IL-2) has fallen out of favor due to severe life-threatening side effects. We have recently described a unique way of directly targeting IL-2 to cytotoxic lymphocytes using a virally encoded immune evasion protein and an IL-2 mutant that avoids off-target side effects such as activation of regulatory T cells and vascular endothelium.