Disordered RNA chaperones can enhance nucleic acid folding via local charge screening
oleh: Erik D. Holmstrom, Zhaowei Liu, Daniel Nettels, Robert B. Best, Benjamin Schuler
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-06-01 |
Deskripsi
RNA chaperones, such as the hepatitic C virus (HCV) core protein, are proteins that aid in the folding of nucleic acids. Here authors use single‐molecule spectroscopy and simulation to show that the HCV core protein acts as a flexible macromolecular counterion which facilitates nucleic acid folding.