In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity
oleh: Nicholas C. Wu, Geramie Grande, Hannah L. Turner, Andrew B. Ward, Jia Xie, Richard A. Lerner, Ian A. Wilson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-05-01 |
Deskripsi
Broadly neutralizing antibodies (bnAbs) against influenza hemagglutinin (HA) have yielded insights for antiviral development. Here, the authors employ saturated mutagenesis of the paratope region of a bnAb combined with yeast display screening using H1 and H3 HAs, and find that a tradeoff exists between Ab affinity and breadth that influenced by disparate modes of receptor binding.