Immunomodulatory role of Keratin 76 in oral and gastric cancer
oleh: Inês Sequeira, Joana F. Neves, Dido Carrero, Qi Peng, Natalia Palasz, Kifayathullah Liakath-Ali, Graham M. Lord, Peter R. Morgan, Giovanna Lombardi, Fiona M. Watt
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-08-01 |
Deskripsi
Keratin 76 (Krt76) is an epithelial differentiation marker that is downregulated in oral squamous cell carcinomas, correlating with poor prognosis. Here the authors show that genetic ablation of Krt76 in a mouse model results in increased susceptibility to carcinogenesis via enhanced accumulation of Tregs.