Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity
oleh: Muaz Nik Rushdi, Victor Pan, Kaitao Li, Hyun-Kyu Choi, Stefano Travaglino, Jinsung Hong, Fletcher Griffitts, Pragati Agnihotri, Roy A. Mariuzza, Yonggang Ke, Cheng Zhu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
It is known that the T cell co-receptor CD4 greatly enhances the capacity of T cell receptor (TCR) signalling, triggered by the peptide-bound MHC molecule. Here authors show that the mechanistic basis for the enhancement is the co-operative binding of TCR and CD4 to the MHC-peptide complex.