The 3D mutational constraint on amino acid sites in the human proteome
oleh: Bian Li, Dan M. Roden, John A. Capra
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-06-01 |
Deskripsi
Here, Li et al. integrate population genetic and protein structural perspectives to map the landscape of 3D constraint on 80% of human proteins. They show that 3D mutational constraint is pervasive and strongly associated with functional relevance.